Paradoxical sleep deprivation increases plasma endothelin levels

Paradoxical sleep deprivation increases plasma endothelin levels

Autor Palma, Beatriz Duarte Autor UNIFESP Google Scholar
Gabriel Junior, Alexandre Autor UNIFESP Google Scholar
Bignotto, Magda Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA). OSA patients exhibit repetitive episodes of apnea and hypopnea that result in hypoxia and consecutive arousals. These patients are chronically sleep deprived, which may aggravate the hypertensive features, since literature data show that sleep deprivation results in hypertension both in humans and in animals. Based on the reported relationship between ET-1, hypertension and sleep deprivation consequences, the purpose of the present study was to determine plasma ET concentrations in paradoxical sleep-deprived animals. Male Wistar rats, 3 to 4 months old (N = 10 per group), were deprived of sleep for 24 and 96 h by the platform technique and plasma ET-1/2 was measured by radioimmunoassay. Analysis of plasma revealed that 96 h of sleep deprivation induced a significant increase in ET-1/2 release (6.58 fmol/ml) compared to control (5.07 fmol/ml). These data show that sleep deprivation altered plasma ET-1/2 concentrations, suggesting that such an increase may participate in the genesis of arterial hypertension and cardiorespiratory changes observed after sleep deprivation.
Palavra-chave Endothelin
Sleep deprivation
Rat
Hypertension
Idioma Inglês
Data de publicação 2002-01-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 1, p. 75-79, 2002.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 75-79
Fonte http://dx.doi.org/10.1590/S0100-879X2002000100011
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000173942600011
SciELO S0100-879X2002000100011 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1330

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