Antinociceptive and antiinflammatory activities of the aqueous extract and isolated Cuphea carthagenensis (Jacq.) J. F. Macbr.

Antinociceptive and antiinflammatory activities of the aqueous extract and isolated Cuphea carthagenensis (Jacq.) J. F. Macbr.

Author Fernandes, Francis Rigolo Autor UNIFESP Google Scholar
Santos, André Luis Dos Autor UNIFESP Google Scholar
Arruda, Ana Maria Soares De Google Scholar
Vasques-pinto, Luciana De Miranda C. Autor UNIFESP Google Scholar
Godinho, Rosely Oliveira Autor UNIFESP Google Scholar
Torres, Luce Maria Brandão Autor UNIFESP Google Scholar
Lapa, Antonio José Autor UNIFESP Google Scholar
Souccar, Caden Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Paraná Department of Pharmacology
Abstract The aqueous extract (AE) and isolated fraction (ppt-3) of Cuphea carthagenensis (Jacq.) J. F. Macbr (sete-sangrias) were tested using models of nociception and inflammation in mice. Oral administration (p.o.) of the AE (10 to 100 mg/kg) and fraction ppt-3 (0.1 to 10 mg/kg) reduced the acetic acid-induced writhing in mice by 40 to 50% and by 46 to 70% of control, respectively. At the same doses AE and ppt-3 did not affect the tail flick response. Fraction ppt-3 also reduced the carrageenininduced paw edema, but at a dose 1000 times higher than that inducing antinociception. The results indicated the presence in the plant of antinociceptive constituents devoid of antiinflammatory activity, with actions apparently mediated by non-opioid mechanisms.
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2002-01-01
Published in Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 12, p. 55-56, 2002.
ISSN 0102-695X (Sherpa/Romeo)
Publisher Sociedade Brasileira de Farmacognosia
Extent 55-56
Origin http://dx.doi.org/10.1590/S0102-695X2002000300027
Access rights Open access Open Access
Type Article
SciELO ID S0102-695X2002000300027 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/1316

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