Author |
Fernandes, Francis Rigolo
![]() ![]() Santos, André Luis Dos ![]() ![]() Arruda, Ana Maria Soares De ![]() Vasques-pinto, Luciana De Miranda C. ![]() ![]() Godinho, Rosely Oliveira ![]() ![]() Torres, Luce Maria Brandão ![]() ![]() Lapa, Antonio José ![]() ![]() Souccar, Caden ![]() ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) Universidade Federal do Paraná Department of Pharmacology |
Abstract | The aqueous extract (AE) and isolated fraction (ppt-3) of Cuphea carthagenensis (Jacq.) J. F. Macbr (sete-sangrias) were tested using models of nociception and inflammation in mice. Oral administration (p.o.) of the AE (10 to 100 mg/kg) and fraction ppt-3 (0.1 to 10 mg/kg) reduced the acetic acid-induced writhing in mice by 40 to 50% and by 46 to 70% of control, respectively. At the same doses AE and ppt-3 did not affect the tail flick response. Fraction ppt-3 also reduced the carrageenininduced paw edema, but at a dose 1000 times higher than that inducing antinociception. The results indicated the presence in the plant of antinociceptive constituents devoid of antiinflammatory activity, with actions apparently mediated by non-opioid mechanisms. |
Language | English |
Sponsor |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) |
Date | 2002-01-01 |
Published in | Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 12, p. 55-56, 2002. |
ISSN | 0102-695X (Sherpa/Romeo) |
Publisher | Sociedade Brasileira de Farmacognosia |
Extent | 55-56 |
Origin |
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Access rights | Open access ![]() |
Type | Article |
SciELO ID | S0102-695X2002000300027 (statistics in SciELO) |
URI | http://repositorio.unifesp.br/handle/11600/1316 |
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