Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats

Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats

Autor Silva, N.f. Google Scholar
Pires, J.g.p. Google Scholar
Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Futuro Neto, H.a. Google Scholar
Instituição Universidade Federal do Espírito Santo Centro Biomédico Departamento de Ciências Fisiológicas
FAESA Faculdade de Saúde de Vitória
Universidade Federal de São Paulo (UNIFESP)
Resumo The role of the caudal pressor area (CPA) in the maintenance of vasomotor tonus in anesthetized and decerebrate animals has been clearly established. In conscious animals, however, the participation of CPA in the cardiovascular control remains to be fully elucidated. In the present study, unilateral L-glutamate (L-Glu) (10 and/or 20 nmol/70 nl) microinjection into CPA, in conscious male Wistar rats (250-280 g) caused a significant increase in mean arterial blood pressure (MAP; control: 112 ± 1.9 mmHg; after 20 nmol L-Glu: 139 ± 4.5 mmHg, N = 12, P<0.05) and respiratory rate (control: 81 ± 3.5 breaths/min; after 10 nmol L-Glu: 92 ± 3 breaths/min, P<0.05; after 20 nmol L-Glu: 104 ± 5 breaths/min, N = 6, P<0.05). The subsequent anesthesia with urethane caused a significant increase in basal respiratory frequency (conscious: 81 ± 3.5 breaths/min; under urethane: 107 ± 1.3 breaths/min, N = 6, P<0.05). Anesthesia also significantly attenuated L-Glu-evoked pressor (conscious: deltaMAP = +27 mmHg; anesthetized: deltaMAP = +18 mmHg, P<0.05) and respiratory responses. These results suggest that glutamatergic receptors in the CPA are involved in cardiovascular and respiratory modulation in conscious rats.
Palavra-chave caudal pressor area
ventrolateral medulla
blood pressure
L-glutamate
respiration
Idioma Inglês
Data de publicação 2001-12-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 12, p. 1603-1606, 2001.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1603-1606
Fonte http://dx.doi.org/10.1590/S0100-879X2001001200013
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000172765500013
SciELO S0100-879X2001001200013 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1300

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