Intracavernous injection in the treatment of erectile dysfunction after radical prostatectomy: an observational study

Intracavernous injection in the treatment of erectile dysfunction after radical prostatectomy: an observational study

Author Claro, Joaquim De Almeida Autor UNIFESP Google Scholar
Aboim, José Elêrton De Autor UNIFESP Google Scholar
Maríngolo, Marcelo Autor UNIFESP Google Scholar
Andrade, Enrico Autor UNIFESP Google Scholar
Aguiar, Wilson Autor UNIFESP Google Scholar
Nogueira, Marcos Autor UNIFESP Google Scholar
Nardozza Júnior, Archimedes Autor UNIFESP Google Scholar
Srougi, Miguel Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract CONTEXT: Despite the recent improvements in performing radical retropubic prostatectomy that have led to a considerable decrease in the complication rate, erectile dysfunction still represents a major problem. Moreover, less invasive treatment options that are emerging for erectile dysfunction have not shown satisfactory results in managing these patients. OBJECTIVE: To study the efficacy and side effects of self-injection therapy in the treatment of men who had become impotent after undergoing radical prostatectomy due to prostate cancer, over a study period of 96 months. DESIGN: Observational study. SETTING: University Referral Center. PARTICIPANTS: 168 patients with erectile dysfunction, aged 43 to 78 years old, who underwent radical retropubic prostatectomy due to localized prostate cancer. PROCEDURES: The patients were treated with self-injection therapy using papaverine, phentolamine and prostaglandin E1, at home. RESULTS: This study showed an acceptable 94.6% success rate, with no life-threatening complications. In addition to this, our series presented a 13.1% cure rate with this therapy. CONCLUSION: Self-injection therapy with papaverine, phentolamine and prostaglandin E1 is effective and safe in the treatment of erectile dysfunction after radical prostatectomy.

CONTEXTO: Apesar do recente avanço técnico na realização da prostatectomia radical retropúbica, que levou a queda no índice de complicações, a disfunção erétil ainda é um problema importante. Além disso, as novas opções (menos invasivas) de tratamento da disfunção erétil não mostram resultados satisfatórios nesse grupo de pacientes. OBJETIVO: Avaliar a eficácia e efeitos colaterais da auto-injeção no tratamento da disfunção erétil causada pela prostatectomia radical, durante 96 meses. TIPO DE ESTUDO: Estudo observacional. LOCAL: Universidade Federal de São Paulo (UNIFESP)/Escola Paulista de Medicina. PARTICIPANTES: 168 pacientes com disfunção erétil, entre 43 e 78 anos, submetidos a prostatectomia radical retropúbica, devido a câncer localizado da próstata. PROCEDIMENTOS: Os pacientes foram tratados com auto-injeção utilizando a associação de papaverina, fentolamina e prostaglandina E1 em casa. RESULTADOS: O índice de sucesso foi de 94,6% com complicações bastante discretas. Além disso, tivemos um índice de cura de 13,1% nesse estudo. CONCLUSÕES: A auto-injeção com papaverina, fentolamina e prostaglandina E1 é eficaz e segura no tratamento da disfunção erétil causada pela prostatectomia radical.
Keywords Prostate cancer
Erectile dysfunction
Self-injection therapy
Radical prostatectomy
Câncer da próstata
Disfunção erétil
Auto-injeção intracavernosa
Prostatectomia radical
Language English
Date 2001-07-01
Published in São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 119, n. 4, p. 135-137, 2001.
ISSN 1516-3180 (Sherpa/Romeo)
Publisher Associação Paulista de Medicina - APM
Extent 135-137
Access rights Open access Open Access
Type Article
SciELO ID S1516-31802001000400004 (statistics in SciELO)

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