Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

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dc.contributor.author Nader, Helena Bonciani [UNIFESP]
dc.contributor.author Pinhal, Maria Aparecida da Silva [UNIFESP]
dc.contributor.author Baú, Elaine Cristina [UNIFESP]
dc.contributor.author Castro, Ricardo Augusto Braga de [UNIFESP]
dc.contributor.author Medeiros, Guilherme Fulgencio [UNIFESP]
dc.contributor.author Chavante, Suely Ferreira [UNIFESP]
dc.contributor.author Leite, Edda Lisboa [UNIFESP]
dc.contributor.author Trindade, Edvaldo da Silva [UNIFESP]
dc.contributor.author Shinjo, Samuel Katsuyuki [UNIFESP]
dc.contributor.author Rocha, Hugo Alexandre Oliveira [UNIFESP]
dc.contributor.author Tersariol, Ivarne Luis dos Santos [UNIFESP]
dc.contributor.author Mendes, Aline [UNIFESP]
dc.contributor.author Dietrich, Carl Peter [UNIFESP]
dc.date.accessioned 2015-06-14T13:29:25Z
dc.date.available 2015-06-14T13:29:25Z
dc.date.issued 2001-06-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2001000600002
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 6, p. 699-709, 2001.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/1184
dc.description.abstract The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate. en
dc.format.extent 699-709
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject heparin, anticlotting activity en
dc.subject heparan sulfate, antithrombotic activity en
dc.subject low molecular weight heparins, preparation and antithrombotic activity en
dc.subject antithrombotic agents, development for clinical use en
dc.subject crustacean heparin-like compounds, antithrombotic activity en
dc.subject antithrombotic agents en
dc.subject vascular endothelial cells en
dc.title Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal do Rio Grande do Norte Departamento de Oceanografia
dc.contributor.institution Universidade Federal do Rio Grande do Norte Departamento de Bioquímica
dc.contributor.institution Universidade de Mogi das Cruzes Centro de Investigação Bioquímica
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Bioquímica
dc.description.affiliation Universidade Federal do Rio Grande do Norte Departamento de Oceanografia
dc.description.affiliation Universidade Federal do Rio Grande do Norte Departamento de Bioquímica
dc.description.affiliation Universidade de Mogi das Cruzes Centro de Investigação Bioquímica
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Bioquímica
dc.identifier.file S0100-879X2001000600002.pdf
dc.identifier.scielo S0100-879X2001000600002
dc.identifier.doi 10.1590/S0100-879X2001000600002
dc.description.source SciELO
dc.identifier.wos WOS:000169443400002



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