Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

Autor Nader, Helena Bonciani Autor UNIFESP Google Scholar
Pinhal, Maria Aparecida da Silva Autor UNIFESP Google Scholar
Baú, Elaine Cristina Autor UNIFESP Google Scholar
Castro, Ricardo Augusto Braga de Autor UNIFESP Google Scholar
Medeiros, Guilherme Fulgencio Autor UNIFESP Google Scholar
Chavante, Suely Ferreira Autor UNIFESP Google Scholar
Leite, Edda Lisboa Autor UNIFESP Google Scholar
Trindade, Edvaldo da Silva Autor UNIFESP Google Scholar
Shinjo, Samuel Katsuyuki Autor UNIFESP Google Scholar
Rocha, Hugo Alexandre Oliveira Autor UNIFESP Google Scholar
Tersariol, Ivarne Luis dos Santos Autor UNIFESP Google Scholar
Mendes, Aline Autor UNIFESP Google Scholar
Dietrich, Carl Peter Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio Grande do Norte Departamento de Oceanografia
Universidade Federal do Rio Grande do Norte Departamento de Bioquímica
Universidade de Mogi das Cruzes Centro de Investigação Bioquímica
Resumo The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate.
Palavra-chave heparin, anticlotting activity
heparan sulfate, antithrombotic activity
low molecular weight heparins, preparation and antithrombotic activity
antithrombotic agents, development for clinical use
crustacean heparin-like compounds, antithrombotic activity
antithrombotic agents
vascular endothelial cells
Idioma Inglês
Data de publicação 2001-06-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 6, p. 699-709, 2001.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 699-709
Fonte http://dx.doi.org/10.1590/S0100-879X2001000600002
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000169443400002
SciELO S0100-879X2001000600002 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1184

Exibir registro completo




Arquivo

Nome: S0100-879X2001000600002.pdf
Tamanho: 269.2KB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta