Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

Author Nader, Helena Bonciani Autor UNIFESP Google Scholar
Pinhal, Maria Aparecida da Silva Autor UNIFESP Google Scholar
Baú, Elaine Cristina Autor UNIFESP Google Scholar
Castro, Ricardo Augusto Braga de Autor UNIFESP Google Scholar
Medeiros, Guilherme Fulgencio Autor UNIFESP Google Scholar
Chavante, Suely Ferreira Autor UNIFESP Google Scholar
Leite, Edda Lisboa Autor UNIFESP Google Scholar
Trindade, Edvaldo da Silva Autor UNIFESP Google Scholar
Shinjo, Samuel Katsuyuki Autor UNIFESP Google Scholar
Rocha, Hugo Alexandre Oliveira Autor UNIFESP Google Scholar
Tersariol, Ivarne Luis dos Santos Autor UNIFESP Google Scholar
Mendes, Aline Autor UNIFESP Google Scholar
Dietrich, Carl Peter Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio Grande do Norte Departamento de Oceanografia
Universidade Federal do Rio Grande do Norte Departamento de Bioquímica
Universidade de Mogi das Cruzes Centro de Investigação Bioquímica
Abstract The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate.
Keywords heparin, anticlotting activity
heparan sulfate, antithrombotic activity
low molecular weight heparins, preparation and antithrombotic activity
antithrombotic agents, development for clinical use
crustacean heparin-like compounds, antithrombotic activity
antithrombotic agents
vascular endothelial cells
Language English
Date 2001-06-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 6, p. 699-709, 2001.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 699-709
Origin http://dx.doi.org/10.1590/S0100-879X2001000600002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000169443400002
SciELO ID S0100-879X2001000600002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/1184

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