Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells

Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells

Autor Furlanetto, Tania Weber Autor UNIFESP Google Scholar
Nunes Jr., R.b. Google Scholar
Sopelsa, A.m.i. Google Scholar
Maciel, Rui Monteiro de Barros Autor UNIFESP Google Scholar
Instituição Universidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina Interna
Universidade Federal de São Paulo (UNIFESP)
Resumo Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.
Palavra-chave iodide uptake
estradiol
thyroid
follicular cells
Idioma Inglês
Data de publicação 2001-02-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 259-263, 2001.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 259-263
Fonte http://dx.doi.org/10.1590/S0100-879X2001000200015
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000167337600015
SciELO S0100-879X2001000200015 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1100

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