Enterococcus faecalis resistant to vancomycin and teicoplanin (VanA phenotype) isolated from a bone marrow transplanted patient in Brazil

Enterococcus faecalis resistant to vancomycin and teicoplanin (VanA phenotype) isolated from a bone marrow transplanted patient in Brazil

Autor Cereda, Rosangela F. Autor UNIFESP Google Scholar
Sader, Helio Silva Autor UNIFESP Google Scholar
Jones, Ronald N. Google Scholar
Sejas, Lilian Autor UNIFESP Google Scholar
Machado, Antônia M. Google Scholar
Zanatta, Yara P. Google Scholar
Rego, Sinaida T. M. S. Autor UNIFESP Google Scholar
Medeiros, Eduardo Alexandrino Servolo de Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
University of Iowa College of Medicine Department of Pathology
São Paulo Hospital Central Laboratory
Resumo We report for the first time in Brazil, a patient from whom an Enterococcus faecalis VanA phenotype was isolated. Glycopeptide resistance is not commonly observed in Enterococcus faecalis, so this finding is of great concern since this species is responsible for 90% of enterococcal infections in Brazil. The isolate was recovered from a surveillance rectal swab culture from a patient with acute lymphocytic leukemia (ALL). Identification to the species level was performed by conventional biochemical tests and Vitek GPI cards. Antimicrobial susceptibility testing was evaluated by use of broth microdilution and Etest (AB BIODISK, Solna, Sweden) methods. The isolate was identified as E. faecalis and was considered resistant to both vancomycin (MIC, > 256 mug/mL) and teicoplanin (MIC, 256 mug/mL). The isolate also showed high level resistance to gentamicin and streptomycin (MICs, > 1024 mug/mL), but was considered susceptible to ampicillin (MIC, 4 mug/mL). Although the frequency of enterococcal infections is very low in most Latin America countries, the finding of glycopeptide (VanA) resistance in E. faecalis increases concern about apreading antimicrobial resistance in this region.
Palavra-chave Enterococcus faecalis
glycopeptide resistance
initial case report
Idioma Inglês
Data de publicação 2001-02-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 5, n. 1, p. 40-46, 2001.
ISSN 1413-8670 (Sherpa/Romeo)
Publicador Brazilian Society of Infectious Diseases
Extensão 40-46
Fonte http://dx.doi.org/10.1590/S1413-86702001000100007
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1413-86702001000100007 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1098

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