Nutritional status of hemodialysis patients with secondary hyperparathyroidism

Nutritional status of hemodialysis patients with secondary hyperparathyroidism

Autor Rezende, Luciana Trindade Teixeira Autor UNIFESP Google Scholar
Cuppari, Lilian Autor UNIFESP Google Scholar
Carvalho, A.b. Autor UNIFESP Google Scholar
Canziani, Maria Eugênia Fernandes Autor UNIFESP Google Scholar
Manfredi, Sílvia Regina Autor UNIFESP Google Scholar
Cendoroglo Neto, Miguel Autor UNIFESP Google Scholar
Sigulem, Dirce Maria Autor UNIFESP Google Scholar
Draibe, Sergio Antonio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The repercussions of secondary hyperparathyroidism on the nutritional status of chronic renal failure patients have not been well established. Therefore, the aim of this study was to compare the nutritional indices of hemodialysis patients with and without secondary hyperparathyroidism. Sixteen hemodialysis patients with serum parathyroid hormone (PTH) levels higher than 420 pg/ml (hyperparathyroidism group) were matched for gender, age and length of dialysis treatment to 16 patients with serum PTH between 64 and 290 pg/ml (control group). The following parameters were assessed: anthropometric indices (body mass index, skinfold thickness, midarm muscle circumference and body fat), 4-day food diaries, protein catabolic rate, biochemical indices (blood urea nitrogen, serum creatinine, albumin, ionized calcium, inorganic phosphorus, serum alkaline phosphatase, PTH, pH and HCO3) and dialysis efficiency. We did not observe differences in the anthropometric indices between the two groups. Only calcium intake was significantly different between groups (307.9 mg/day for the hyperparathyroidism group vs 475.8 mg/day for the control group). Protein catabolic rate tended to be higher in the hyperparathyroidism group compared to the control group (1.3 vs 0.9 g kg-1 day-1; P = 0.08). Except for blood urea nitrogen (86.4 vs 75.7 mg/dl), alkaline phosphatase (175 vs 65 U/l) and PTH (898 vs 155 pg/ml), no other differences were found between groups in the biochemical indices studied. PTH was directly correlated with protein catabolic rate (r = 0.61; P<0.05) and length of dialysis (r = 0.53; P<0.05) only in the hyperparathyroidism group. Considering the indices used, we could not demonstrate the deleterious effect of high PTH levels on the nutritional status of hemodialysis patients. Indirect evidence, however, suggests an action of PTH on protein metabolism.
Assunto nutritional assessment
parathormone
chronic renal failure
secondary hyperparathyroidism
Idioma Inglês
Data 2000-11-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 33, n. 11, p. 1305-1311, 2000.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Editor Associação Brasileira de Divulgação Científica
Extensão 1305-1311
Fonte http://dx.doi.org/10.1590/S0100-879X2000001100007
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000165487100007
SciELO S0100-879X2000001100007 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/1049

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