The brain decade in debate: I. Neurobiology of learning and memory

The brain decade in debate: I. Neurobiology of learning and memory

Author Baddeley, Alan Google Scholar
Bueno, Orlando Francisco Amodeo Autor UNIFESP Google Scholar
Cahill, Larry Google Scholar
Fuster, Joaquin .m. Google Scholar
Izquierdo, Ivan Antônio Google Scholar
Mcgaugh, James.l Google Scholar
Morris, Richard.g.m. Google Scholar
Nadel, Lynn Google Scholar
Routtenberg, A. Google Scholar
Xavier, Gilberto Fernando Google Scholar
Da Cunha, Cláudio Google Scholar
Institution University of Bristol Department of Psychology
Universidade Federal de São Paulo (UNIFESP)
University of California Center for Neurobiology of Learning and Memory Department of Neurobiology and Behavior
University of California Neuropsychiatric Institute
Universidade Federal do Rio Grande do Sul Instituto de Biociências Departamento de Bioquímica
University of Edinburgh Department of Neuroscience
University of Arizona Department of Psychology
Northwestern University
Universidade de São Paulo (USP)
Universidade Federal do Paraná Departamento de Farmacologia Laboratório de Fisiologia e Farmacologia do Sistema Nervoso Central
Abstract This article is a transcription of an electronic symposium in which some active researchers were invited by the Brazilian Society for Neuroscience and Behavior (SBNeC) to discuss the last decade's advances in neurobiology of learning and memory. The way different parts of the brain are recruited during the storage of different kinds of memory (e.g., short-term vs long-term memory, declarative vs procedural memory) and even the property of these divisions were discussed. It was pointed out that the brain does not really store memories, but stores traces of information that are later used to create memories, not always expressing a completely veridical picture of the past experienced reality. To perform this process different parts of the brain act as important nodes of the neural network that encode, store and retrieve the information that will be used to create memories. Some of the brain regions are recognizably active during the activation of short-term working memory (e.g., prefrontal cortex), or the storage of information retrieved as long-term explicit memories (e.g., hippocampus and related cortical areas) or the modulation of the storage of memories related to emotional events (e.g., amygdala). This does not mean that there is a separate neural structure completely supporting the storage of each kind of memory but means that these memories critically depend on the functioning of these neural structures. The current view is that there is no sense in talking about hippocampus-based or amygdala-based memory since this implies that there is a one-to-one correspondence. The present question to be solved is how systems interact in memory. The pertinence of attributing a critical role to cellular processes like synaptic tagging and protein kinase A activation to explain the memory storage processes at the cellular level was also discussed.
Keywords memory
memory systems
Language English
Date 2000-09-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 33, n. 9, p. 993-1002, 2000.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 993-1002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000089558500002
SciELO ID S0100-879X2000000900002 (statistics in SciELO)

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