Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography

Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography

Autor Moisés, Valdir Ambrósio Autor UNIFESP Google Scholar
Ferreira, Ricardo L. Autor UNIFESP Google Scholar
Nozawa, Emília Autor UNIFESP Google Scholar
Kanashiro-Takeuchi, Rosimeire Miyuki Autor UNIFESP Google Scholar
Campos Filho, Orlando Autor UNIFESP Google Scholar
Andrade, José Lazaro de Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos Autor UNIFESP Google Scholar
Tucci, Paulo José Ferreira Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.
Palavra-chave myocardial infarct
rat hearts
Doppler echocardiogram
Idioma Inglês
Data de publicação 2000-08-01
Publicado em Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 2, p. 131-136, 2000.
ISSN 0066-782X (Sherpa/Romeo)
Publicador Sociedade Brasileira de Cardiologia - SBC
Extensão 131-136
Fonte http://dx.doi.org/10.1590/S0066-782X2000000800005
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0066-782X2000000800005 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1011

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